Systematic review on neural correlates of the pharmacological treatment of alcohol dependence

• Grant number: 19/18034-5
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: November 01, 2019
• End date: October 31, 2020
• Field of knowledge: Health Sciences - Medicine - Psychiatry
• Principal Investigator: João Mauricio Castaldelli Maia
• Grantee: Luiza Larrubia Alvares Florence
• Host Institution: Centro Universitário Saúde ABC. Fundação do ABC. Santo André , SP, Brazil

Abstract

Alcohol use disorder (AUD) is prevalent, with multifactorial causes and a chronic course. Pharmacological treatment is an important part of the treatment. However, medications' neural effects are not entirely clear. Objectives: To summarize the neural effects of the medications approved for AUD's treatment through neuroimaging studies. It could guide AUD neural subtypes treatment, and support the investigation of other psychotropic drugs with similar effects. Methods: We will search the following keywords on PubMed, Scielo and PsycINFO database: (naltrexone OR disulfiram OR topiramate OR acamprosate OR gabapentin) and (alcoho*) and (neuroimage OR neuroimaging OR magnetic resonance OR smri OR structural magnetic resonance OR SPECT OR fmri OR functional magnetic resonance OR pet OR positron emission tomography). Original articles of alcohol-dependent individuals, published in the Portuguese, English or Spanish language with pharmacological treatment of alcohol dependence and use of functional magnetic resonance imaging (fMRI) or PET scan were included in this review. Expected results: The ventral striatum, pre-frontal cortex, anterior cingulate cortex, occipital-lateral cortex, orbitofrontal cortex, posterior cingulate cortex, front cortex, among other areas are highly involved in the maintaining and abstinence mechanisms involved with use of alcohol. It is believed that the drugs included in the 2017 APA's Guideline present their different functional effects on such regions. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FLORENCE, LUIZA; LASSI, DANGELA LAYNE SILVA; KORTAS, GUILHERME T.; LIMA, DANIELLE R.; DE AZEVEDO-MARQUES PERICO, CINTIA; ANDRADE, ARTHUR G.; TORALES, JULIO; VENTRIGLIO, ANTONIO; DE BERARDIS, DOMENICO; DE AQUINO, JOAO P.; et al. Brain Correlates of the Alcohol Use Disorder Pharmacotherapy Response: A Systematic Review of Neuroimaging Studies. BRAIN SCIENCES, v. 12, n. 3, p. 15-pg., 2022-03-01. (19/18034-5)