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Participation of astrocytes in the modulation of NTS neurons involved in the processing of cardiovascular and respiratory components of the chemoreflex of rats submitted to maintained hypoxia

Grant number: 19/21328-0
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): January 01, 2020
Effective date (End): April 30, 2022
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal researcher:Benedito Honorio Machado
Grantee:Darlan da Silva Bazilio
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:18/15957-2 - Astrocytic modulation on brainstem neurons involved with generation and control of sympathetic and respiratory activities in rodents submitted to hypoxia, AP.TEM

Abstract

Activation of peripheral chemoreflex induces bradycardia, elevated blood pressure, active expiration and tachypnea. The first synapse of chemoreceptor afferents occurs in the commissural region of the Nucleus Tractus Solitarius (NTS). Studies from our laboratory suggest that astrocytes participate, via ATP release, in the processing of chemoreflex responses in the NTS. In addition, our laboratory showed that sustained hypoxia (SH, FiO2 = 0.1 for 24 hours) increased intrinsic excitability and excitatory neurotransmission in NTS neurons, as well as the chemoreflex sympathetic response. In this project we will study the participation of astrocytes and glutamatergic and purinergic mechanisms in the processing of chemoreflex autonomic and respiratory responses in different NTS subregions, in control rats and rats submitted to SH. This project will allow a better characterization of peripheral chemoreflex processing in the NTS, the role of astrocyte-neuron interaction in this processing and the possible effects of glial dysfunction produced by HM on neurotransmission in the NTS. (AU)

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