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KRAS oncogene amplification study in testicular germ cell tumors

Grant number: 19/14512-0
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): December 01, 2019
Effective date (End): November 30, 2020
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Flavio Mavignier Cárcano
Grantee:Marilia Ferreira Pacanhella
Home Institution: Hospital do Câncer de Barretos. Fundação Pio XII (FP). Barretos , SP, Brazil

Abstract

Testicular cancer is the most common solid tumor in young men in the 20-35 years and it is the second cause of death in cancer patients of this age group. It is a neoplasia with high curative potential, however, patients with extra-testicular disease and intermediate/poor risk may have an unfavorable outcome. Alterations in the k-RAS gene have been associated with biology of higher risk and resistance to treatment in several types of cancers. The role of molecular alterations of the k-RAS gene in testicular cancer has been little explored. Objectives: This study aims to evaluate the amplification of the k-RAS gene in patients with testicular germ cell tumor (TCGT). Materials and Methods: The target audience for this study are patients diagnosed with intermediate/poor risk TCGT. Variation analysis on the number of copies of the k-RAS gene will be performed through a specific assay, using a duplex PCR reaction, with positive and negative controls. (AU)

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