The influence of GPR120 in the immune system

• Grant number: 19/13168-3
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: February 01, 2020
• End date: November 30, 2023
• Field of knowledge: Health Sciences - Nutrition
• Principal Investigator: Dennys Esper Corrêa Cintra
• Grantee: Susana Castelo Branco Ramos Nakandakari
• Host Institution: Faculdade de Ciências Aplicadas (FCA). Universidade Estadual de Campinas (UNICAMP). Limeira , SP, Brazil
• Associated scholarship(s): 21/14996-7 - The reprogramming of gluconeogenesis and gpr120 expression in sepsis metabolism, BE.EP.DD

Abstract

The protective effects of omega 3 fatty acids (É3) have been the subject of studies for decades. Studies have shown that É3 has an effect on the reduction of inflammatory frames, on the reduction of platelet aggregation, on the improvement of insulin sensitivity, on the immune system, among others. Among the mechanisms by which É3 acts, the activation of the GPR120 receptor shows to be important. The receptor, once activated, is able to attenuate the inflammatory process through the block of the intracellular NFkB signaling pathway, consecutively reducing the expression of pro-inflammatory cytokine genes, such as TNF±, IL1², iNOS etc. Works from our group demonstrated the presence of GPR120 in the hypothalamus, liver, muscle, adipose tissue, aorta and retina. In addition, GPR120 has been described in immune system-specific cells, such as Kupffer cells and infiltrated macrophages into the endothelial wall. In the Central Nervous System (CNS), microglia play an important role in brain development, memory and cognition, control of food intake and energy expenditure. Once the activity of this receptor in these specific tissues has been demonstrated, it is hypothesized that the GPR120 receptor expressed on the surface of macrophages/microglia can be activated by É3 fatty acids and therefore its polarization ordered to an anti-inflammatory profile (M2). If this hypothesis is confirmed, this could constitute new strategies of drug/nutritional intervention. Perhaps the GPR120 is one more piece, fundamentally involved in the control of the immune system. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BATISTA, ELLENCRISTINA DA SILVA; BRANCO RAMOS NAKANDAKARI, SUSANA CASTELO; RAMOS DA SILVA, ADELINO SANCHEZ; PAULI, JOSE RODRIGO; DE MOURA, LEANDRO PEREIRA; ROPELLE, EDUARDO ROCHETE; CAMARGO, ENILTON A.; CINTRA, DENNYS ESPER. Omega-3 pleiad: The multipoint anti-inflammatory strategy. CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, v. N/A, p. 16-pg., 2022-11-10. (20/13443-1, 19/13210-0, 19/13168-3)

NAKANDAKARI, SUSANA CASTELO BRANCO RAMOS; GASPAR, RAFAEL CALAIS; KUGA, GABRIEL KEINE; RAMOS, CAMILA DE OLIVEIRA; VIEIRA, RENAN FUDOLI; RIOS, THAIANE DA SILVA; MUNOZ, VITOR ROSETTO; SANT'ANA, MARCELLA RAMOS; SIMABUCO, FERNANDO MOREIRA; SILVA, ADELINO SANCHEZ RAMOS DA; et al. Short-term flaxseed oil, rich in omega 3, protects mice against metabolic damage caused by high-fat diet, but not inflammation. JOURNAL OF NUTRITIONAL BIOCHEMISTRY, v. 114, p. 11-pg., 2023-02-11. (19/13168-3, 19/13210-0)

RODRIGUES, PATRICIA BRITO; DATILO, MARCELLA NEVES; SANT'ANA, MARCELLA RAMOS; NOGUEIRA, GUILHERME AUGUSTO DA SILVA; MARIN, RODRIGO MIGUEL; NAKANDAKARI, SUSANA CASTELO BRANCO RAMOS; DE MOURA, LEANDRO PEREIRA; SILVA, ADELINO SANCHEZ RAMOS DA; ROPELLE, EDUARDO ROCHETE; PAULI, JOSE RODRIGO; et al. The early impact of diets enriched with saturated and unsaturated fatty acids on intestinal inflammation and tight junctions. JOURNAL OF NUTRITIONAL BIOCHEMISTRY, v. 119, p. 12-pg., 2023-09-01. (12/07129-6, 19/13168-3, 19/13210-0)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

NAKANDAKARI, Susana Castelo Branco Ramos. The relationship between omega-3 sources and the GPR120 receptor in different inflammatory states. 2023. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Aplicadas Limeira, SP.