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Effects of transcranial direct-current stimulation (tDCS) on blood pressure of spontaneously hypertensive rats (SHR): a functional, inflammatory and epigenetic approach

Grant number: 19/02975-5
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): March 01, 2020
Effective date (End): February 28, 2023
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal researcher:Bruno Rodrigues
Grantee:Olivia Moraes Ruberti
Home Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


Hypertension (HA) is a complex and multifactorial disease, with hyperactivity of the sympathetic nervous system (SNS) and reduction of vagal activity considered some of the main causes of refractoriness to treatment. In addition, in recent years relationships between the autonomic and immune systems have been demonstrated. The possibility of using brain stimulation techniques, such as non-invasive direct current transcranial stimulation (tDCS) in the cerebral cortex in HA may be promising to reduce blood pressure (BP). Previous studies have shown that cortical sympathetic modulation after tDCS may reduce blood pressure levels and improve autonomic function; however, major outcomes were associated with improved psychic depression in non-hypertensive patients. Thus, the present project aims to evaluate in spontaneously hypertensive rats (SHR): 1) the effects of 8 sessions of tDCS, on blood pressure; 2) the effects of tDCS on functional, autonomic and inflammatory variables; 3) to evaluate the effect of tDCS on the pattern of HA-related miRNAs. The animals will be randomly divided into 4 experimental groups: control SHR (SHR-C), SHR group submitted to tDCS (SRH-tDCS), Wistar Kyoto control (WK-C) and Kyoto Wistar rats submitted to tDCS (WK-tDCS ). (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FERIANI, DANIELE J.; SOUSA, ANDRESSA S.; DELBIN, MARIA ANDREIA; RUBERTI, OLIVIA M.; CRESTANI, CARLOS C.; RODRIGUES, BRUNO. Spleen tissue changes after restraint stress: effects of aerobic exercise training. STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS, MAR 2021. Web of Science Citations: 0.

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