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Exploring photochemical reactions for peptide functionalization

Grant number: 20/00684-0
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): March 01, 2020
Effective date (End): February 28, 2022
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Cooperation agreement: GlaxoSmithKline
Principal researcher:Márcio Weber Paixão
Grantee:Pablo Silva Carneiro
Home Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
Associated research grant:14/50249-8 - Green chemistry: sustainable synthetic methods employing benign solvents, safer reagents, and bio-renewable feedstock, AP.PCPE

Abstract

In the last decades, the emphasis and application of the green chemistry principles has driven a change of behavior in both fine chemical industry and academy - towards a more sustainable process - specially by looking for the obtention of desired product with a fewest number of steps, high yield and the use of non-toxic reagents. In this context, the increasing recognition of the environmental benefits presented by photochemical reactions, induced by wavelengths present in the visible light, in face of conventional thermal methods has been stimulated the scientific community in searching for photochemical methodologies that allows the development of new synthetic strategies to obtain biologically active organic compounds. Thus, this research project aims the exploration of synthetic methodologies, using photoredox catalysis processes mediated by the formation of EDA complex. So, the main objective of this research is the development of efficient synthetic procedures for the functionalization of peptide side chains and modifications through the peptide stapling approach. (AU)

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