Structural characterization of DODAB vesicles containing C24:1 sulfatide

• Grant number: 20/01417-6
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: July 01, 2020
• End date: June 30, 2021
• Field of knowledge: Health Sciences - Pharmacy
• Principal Investigator: Julio Henrique Kravcuks Rozenfeld
• Grantee: Lucas de Andrade
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated research grant: 16/13368-4 - Nanostructured systems: from membrane biomimetic models to carriers of bioactives, AP.TEM

Abstract

The C24:1 sulfatide belongs to a family of sulfoglycolipids that perform several important biological functions. It is recognized as an antigen by CD1-restricted T cells; the use of a suitable carrier might result in the activation of these cells with potential immunotherapeutic applications. The cationic lipid DODAB, which has been extensively used as an immunoadjuvant, may serve as an adequate carrier for the C24:1 sulfatide. The aim of this Project is to characterize the structure of DODAB large vesicles containing different molar fractions of C24:1 sulfatide. This characterization will allow interesting assemblies to be tested as immunotherapeutic tools in the future. This Project is attached to the Thematic Grant 2016/13368-4: "Nanostructured systems: from membrane biomimetic models to carriers of bioactives". (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE ANDRADE, LUCAS; DUARTE, EVANDRO L.; LAMY, TERESA; ROZENFELD, JULIO H. K.. Thermotropic Behavior and Structural Organization of C24:1 Sulfatide Dispersions and Its Mixtures with Cationic Bilayers. ACS OMEGA, v. N/A, p. 10-pg., 2023-02-02. (16/19077-1, 16/13368-4, 20/01417-6, 14/50983-3, 21/01593-1)