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Evaluation of the adhesion capacity of fibroblasts derived from vaginal tissue in oxiated cellulose meshes

Grant number: 19/27601-0
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): July 01, 2020
Effective date (End): June 30, 2021
Field of knowledge:Health Sciences - Medicine - Maternal and Child Health
Principal Investigator:Marair Gracio Ferreira Sartori
Grantee:Amanda Botelho
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil


Vaginal and uterine agenesis, also known as Mayer-Rokitansky-Küster-Hauser syndrome (SMRKH), is a congenital malformation that brings important clinical and psychological repercussions due to the impairment of sexual activity and reproductive life. It has an incidence that varies from one case to 4,000 to 5,000 female births. According to data from Datasus, in relation to the number of female live births, in the year 2017 we would have approximately 316 new cases of SMRKH in our country. The treatment of SMRKH aims to provide the patient with a normal sex life. For this, a neovagine is made that must have length and width compatible with a normal vagina and adequate lubrication. The treatment of SMRKH is divided into surgical and incrudent methods. Currently, it is believed that the use of oxiated cellulose meshes populated by autologous cells can improve the results obtained in the surgery. Therefore, we will evaluate the adhesion capacity and viability of fibroblastoid cells derived from vaginal tissue in oxiated cellulose mesh. Primary cells isolated from vaginal tissue will be used and the time and adhesion capacity of these cells as well as the integrity of the oxiated cellulose membranes are evaluated. The results obtained in this project intend to generate parameters for the development of cellulose meshes populated with cells for the treatment of SMRKH. (AU)