Comparative assessment of hyponatremia and hyposmolarity secondary to the use of Ringer acetate, Ringer lactate and modified Ringer lactate as a maintenance fluid during the dogs operation

• Grant number: 20/04270-6
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: August 01, 2020
• End date: July 31, 2021
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
• Principal Investigator: Denise Tabacchi Fantoni
• Grantee: Fernando Scarazati Tolino
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Increasingly, the veterinarian is concerned with improving fluid therapy, many prefer Ringer lactate as a maintenance or replacement solution, especially in anesthetic-surgical procedures due to its hydroelectrolytic similarity in the dog's plasma. Despite this, it is considered a hypotonic solution (such as Ringer acetate), which in humans already exists studies that have pointed out a direct relationship between the use of this type of fluid and a reduction in the serum sodium concentration, resulting in a decrease in the plasma osmolarity of the patient. Aiming to search for the ideal fluid, there are several researches in medicine, which prove iatrogenic dilutional hyponatremia and still propose a solution more similar to plasma to prevent such problems, however, in veterinary medicine, studies are needed to prove this occurrence and bring a more balanced solution for the improvement of care in the perioperative of animals. For this, based on the data obtained in a literature review and assuming that hyposmolarity and hyponatremia occur in the dog with Ringer's lactate solution, 24 animals will be randomly distributed into three groups, each group will have 8 animals, with 1 group receiving Ringer's infusion lactate (GRL, n¹ = 8), a second group will receive an infusion of isotonic Ringer lactate, with a concentration of approximately 0.79% (GRI, n² = 8) and a third group will receive an infusion of Ringer acetate (GRA, n³ = 8 ), all for maintenance during the operation. Blood samples will be collected before, during and at the end of the infusion, for determinations of pH, glycemia, blood gases, bicarbonate, serum lactate, osmolarity and anion gap calculation. (AU)