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Immunohistochemical evaluation of the functionalization of xenograft associated with raloxifene in bone repair through sonication: an experimental study in rabbits

Grant number: 20/04362-8
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): July 01, 2020
Effective date (End): June 30, 2021
Field of knowledge:Health Sciences - Dentistry - Oral and Maxillofacial Surgery
Principal Investigator:Eduardo Hochuli Vieira
Grantee:Marcos Eduardo Gomes Alves
Host Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil


The use of bone substitutes is largely consolidated in boneloss. By functionalization it is possible to promote their provident of these substitutes, starting from the introduction of bioactive molecules that act directly on the bone cells, triggering favorable responses to the tissue repair process. Good results in this repair have been found with the incorporation ofraloxifene to biomaterials, using the sonication process. The objective of this project will be to evaluate, through his to morphometric analysis, immunohistochemistry and computerized microtomography, a surface alteration, through the homogenization and functionalization promoted in the Cerabone® Biomaterial combined with Raloxifene by mean soft hechemical sonication method, increasing of the maxillary sinuses of rabbits. For this, 20 male rabbits will have their maxillary sinuses grafted bilaterally. They will be randomly divided into 04 groups (n = 10 maxillarysinuses), according to the graft material, Group 01 (Autogenous Bone), Group 02 (Cerabone®), Group 03 (Cerabone® sonicated), Group 04 (Cerabone® and Raloxifenesonicated). After a period of 14 and 42 days of performing the surgical procedure for lifting the maxillary sinuses, the euthanasia of the animals will be performed to remove the specimens to be submitted to the analysis. The data will be submitted to the normality curve to determine the appropriate statistical test in the software GraphPad Prism 7.03,with the adoption of the significance level P <0.05. (AU)

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