Effect of type V collagen supplementation on inflammatory process and experimental extracellular arthritis matrix remodeling

• Grant number: 19/24178-0
• Support Opportunities: Scholarships in Brazil - Master
• Start date: August 01, 2020
• End date: July 31, 2022
• Field of knowledge: Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
• Principal Investigator: Walcy Paganelli Rosolia Teodoro
• Grantee: Lizandre Keren Ramos da Silveira
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Joint inflammation, generically described as Arthritis (RA), affects the body's synovial joints. It is typically characterized by the presence of local painful inflammation, swelling and stiffness, causing limitation or loss of function of the involved site. The incidence of RA increases with age, reaching 85% of the population up to 64 years, and this fact results in a significant social impact and degree of disability. The etiology of RA types, where there is no associated autoimmune factor, is still unknown, but it is known that, in pathophysiological parameters, a lymphocyte infiltrate and neoangiogenesis lead to the formation of pannus, which affects the subchondral bone and articular cartilage. Synovial involvement is of great importance in the process of degradation of joint and bone components, however, knowledge about the mechanisms responsible for the degenerative process and the effect of therapies that may retard degeneration are still scarce and invasive. Knowing that RA treatment needs to start earlier and earlier in order to preserve osteocartilaginous structure, and even though the drugs currently used are expensive and often limiting side effects, we postulate that a therapy Aiding the treatment in the early stages of the disease would be of great value to control its evolution. Recent studies from our group have shown that oral ColV supplementation can modulate inflammation and remodeling of joint synovitis in rats. It is still known that ColV can be exposed in tissue remodeling processes, generating autoimmunity in several pathologies. Considering these aspects, the proposal in this project will be to evaluate the mechanisms of action in the RA model after supplementation with ColV in order to identify the efficiency potential of this protein as an alternative therapy in this disease. (AU)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SILVEIRA, Lizandre Keren Ramos da. Effect of collagen V immunotherapy on the inflammatory process and synovial tissue remodeling in experimental arthritis. 2023. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.