Exploring new mechanisms of intercellular communication in metabolic diseases

• Grant number: 20/06057-8
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: September 01, 2020
• End date: September 30, 2025
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Licio Augusto Velloso
• Grantee: Adriana Leandra Santoro
• Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 13/07607-8 - OCRC - Obesity and Comorbidities Research Center, AP.CEPID

Abstract

Cells exchange information via secretion of molecules such as metabolites, proteins and miRNAs. Mechanisms of intercellular communication become disrupted during metabolic diseases, leading to changes in the circulating levels of these molecules. The main purpose of this project is to identify secreted molecules that exert relevant biological functions in the context of metabolic diseases. For that we will use plasma/serum samples of mice and humans undergoing interventions that promote weight loss and we will profile circulating molecules using omics approaches to identify the ones that associate with a healthy metabolic status. Once we identify these molecules, we will test them in a series of cell and animal models to characterize their potential to protect against metabolic diseases. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SANTORO, ADRIANA LEANDRA; VENDRAMINI, PEDRO H.; BRAGA, DEISI L.; MARTINS, LUCAS GELAIN; DOS SANTOS, GABRIEL F.; LIMA, GESIANE S.; TASIC, LJUBICA; MORI, MARCELO A.. Caenorhabditis elegans (C. elegans) sample preparation for metabolomics and lipidomics analysis - A review. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, v. 169, p. 11-pg., 2023-10-25. (13/07607-8, 21/08354-2, 17/01184-9, 20/06057-8, 18/11792-9)