Black pepper extract nanoencapsulation

• Grant number: 20/05292-3
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: June 01, 2021
• End date: June 30, 2022
• Field of knowledge: Health Sciences - Pharmacy
• Principal Investigator: Priscila Gava Mazzola
• Grantee: Bruna Cezario Evangelista dos Santos
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Nanoparticles can be a carrier system of natural compounds, such as black pepper extract, effective and promising for helping and facilitating the bioavailability of compounds and encapsulated drugs. The black pepper extract is widely used in cooking, however it has a great medicinal potential already known in India for presenting healing, antioxidant, antimicrobial and antiparasitic properties, in addition it presents as its component the alkaline piperine which in addition to the properties mentioned can also act increasing bioavailability of drugs. The nanoencapsulation of the extract aims to increase the stability of a natural extract, and also to decrease the pungency that piperine can offer in a topical formulation. Therefore, this project aims to study the extraction of piperine from black pepper, as well as its nanoencapsulation in Poly-µ-caprolactone particles.