Study of antitumor activity of biogenic silver nanoparticles

• Grant number: 20/04799-7
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: August 01, 2020
• End date: October 13, 2022
• Field of knowledge: Health Sciences - Pharmacy
• Principal Investigator: Ana Olívia de Souza
• Grantee: Gabriella Sales Calaço Roque
• Host Institution: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

Data from the United States National Cancer Institute show that death rates from cancer have increased over the years, and the available therapy indicates adverse effects on patients, requiring new alternatives. Biological silver nanoparticles (AgNPs) can be a viable possibility as antitumor treatment, since the protective coating favors its affinity for tumor cells and, consequently, can contribute to the adverse effects reduction. Due to the antitumor agents demand and the potential for applying AgNPs, the aims of this proposal is to study the in vitro and in vivo antitumor action of biogenic AgNPs, based on the cultivation of extremophile fungi from Brazilian biodiversity, such mainly from mangrove and biome Caatinga. It is intended that the study will contribute to providing subsidies and data for a new alternative to current antitumor treatments, with a reduction or absence of adverse effects. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CONRADO, RAFAEL; GOMES, TAINAH COLOMBO; ROQUE, GABRIELLA SALES CALACO; DE SOUZA, ANA OLIVIA. Overview of Bioactive Fungal Secondary Metabolites: Cytotoxic and Antimicrobial Compounds. ANTIBIOTICS-BASEL, v. 11, n. 11, p. 38-pg., 2022-11-01. (20/04799-7)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

ROQUE, Gabriella Sales Calaço. Study of the antitumor action of biogenic silver nanoparticles. 2023. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina Veterinária e Zootecnia (FMVZ/SBD) São Paulo.