Role of TNFR1 and TNFR2 receptors in dental pulp cell differentiation stimulated with tumor necrosis factor-alpha

• Grant number: 20/06607-8
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: November 01, 2020
• End date: October 31, 2021
• Field of knowledge: Health Sciences - Dentistry
• Principal Investigator: Francisco Wanderley Garcia de Paula e Silva
• Grantee: Roberta Duarte Leme
• Host Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Tumor necrosis factor-alpha (TNF-alpha) is a cytokine released by macrophages in the immune- inflammatory response, with a role in induction cell proliferation, migration and differentiation of dental pulp cells. This study aims to evaluate the hypothesis that TNF-alpha signaling via TNFR1 results in inhibition of mineralization, while signaling via TNFR2 leads to cell differentiation. The tests will be carried out with undifferentiated cells from the dental pulp of mice.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LEME, ROBERTA DUARTE; CHAVES LAMARQUE, GIULIANA DE CAMPOS; BASTOS, LAURA ALVES; MANFRIN ARNEZ, MAYA FERNANDA; GARCIA PAULA-SILVA, FRANCISCO WANDERLEY. Minimal Intervention Dentistry: Biocompatibility and Mechanism of Action of Products for Chemical-Mechanical Removal of Carious Tissue. FRONTIERS IN DENTAL MEDICINE, v. 3, p. 6-pg., 2022-04-20. (20/06607-8)