| Grant number: | 21/01190-4 |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| Start date: | May 01, 2021 |
| End date: | April 30, 2022 |
| Field of knowledge: | Health Sciences - Medicine |
| Principal Investigator: | Luiz Henrique Martins Castro |
| Grantee: | Leonardo Zumerkorn Pipek |
| Host Institution: | Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
Abstract Rationale: Idiopathic generalized epilepsy (IGE) is characterized by adolescence onset, absence, myoclonic and generalized tonic clonic (GTC) seizures, and typical EEG findings. Seizures respond to broad-spectrum antiepileptic drugs (AED): VPA, LEV, LTG, TPM. VPA use is limited in women of childbearing potential. Studies evaluating the relative efficacy of these AEDs in mono- and in combination therapies in the clinic setting are scarce. Objective: To compare the efficacy of VPA, LEV and LTG, in mono- and combination therapy in a cohort of IGE patients treated by a single neurologist.Methods: A series of IGE patients (defined by typical seizure types and characteristic EEG pattern) treated with at least one of the study AEDs. We defined three seizure control outcomes: 1- Seizure-free for all types; 2- Only minor non-disabling seizures (absence or myoclonic) 3- Minor seizures and/or pseudoresistence (GTC exclusively with sleep deprivation or medication non-adherence). We will analyzed survival curves for mono- and combination therapies of VPA, LEV and LTG. A treatment period was defined as at least six months on a stable regimen with a positive outcome, or any period for a treatment failure. | |
| News published in Agência FAPESP Newsletter about the scholarship: | |
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