Analysis of immunohistochemical markers related to metastasis and death in papillary thyroid carcinoma

• Grant number: 20/12459-1
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: April 01, 2021
• End date: March 31, 2022
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal Investigator: Ana Kober Nogueira Leite
• Grantee: Luana Perrone Camilo
• Host Institution: Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE). Sociedade Beneficente Israelita Brasileira Albert Einstein (SBIBAE). São Paulo , SP, Brazil

Abstract

Papillary carcinoma is the most common cancer of the thyroid gland. Most patientshave an excellent prognosis, with survival rates ranging from 97 to 99,8%, related toits well-differentiated nature. Even with a low mortality, there are cases in whichpatients develop distant metastasis and that reduces their survival. This situation couldbe associated with several molecular changes, with emphasis on the epitheliummesenchymal transition, its signaling pathway and its markers, such as Twist1. Thus,the objective of this project is to verify, using immunohistochemical markers, molecularchanges that lead to increased invasion and metastasis by the primary tumor. Suchfindings could provide important means of identifying patients at greater risk ofunfavorable evolution at the time of the initial presentation.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LEITE, ANA KOBER; SAITO, KELLY CRISTINA; THEODORO, THERESE RACHELL; PASINI, FATIMA SOLANGE; CAMILO, LUANA PERRONE; ROSSETTI, CARLOS AUGUSTO; CAVALHEIRO, BEATRIZ GODOI; ALVES, VENANCIO AVANCINI FERREIRA; KOWALSKI, LUIZ PAULO; PINHAL, MARIA APARECIDA SILVA; et al. Profile of MicroRNAs Associated with Death Due to Disease Progression in Metastatic Papillary Thyroid Carcinoma Patients. CANCERS, v. 15, n. 3, p. 12-pg., 2023-02-01. (20/12459-1, 19/25116-8)