Functional Characterization of subunit 5 from Anaphase Promoter Complex

• Grant number: 21/03212-5
• Support Opportunities: Scholarships in Brazil - Master
• Effective date (Start): April 01, 2021
• Effective date (End): July 31, 2023
• Field of knowledge: Biological Sciences - Biochemistry - Molecular Biology
• Acordo de Cooperação: Max Planck Society for the Advancement of Science
• Principal Investigator: Nubia Barbosa Eloy
• Grantee: Luís Felipe Correa da Silva
• Host Institution: Escola Superior de Agricultura Luiz de Queiroz (ESALQ). Universidade de São Paulo (USP). Piracicaba , SP, Brazil
• Associated research grant: 17/10333-8 - APC as an entry point to study small molecule regulation of the cell cycle, AP.JP
• Associated scholarship(s): 22/08534-3 - Unbalancing the balance: tracking the alterations in Arabidopsis thaliana metabolome due to changes in APC5 expression, BE.EP.MS

Abstract

The Anaphase Promoter Complex (APC) is a multiprotein complex - an ubiquitin E3 ubiquitin ligand - involved in ubiquitin-dependent proteolysis of cell cycle regulatory proteins, and in which we include the destruction of mitotic cyclins during the metaphase to anaphase transition. The identification of the complete set of genes encoding the APC subunits in Arabidopsis, suggests that the basic processes controlled by ubiquitin-mediated proteolysis in plants are similar to those of other organisms. However, results from several groups indicate that the APC has other specific functions in the regulation of plant development. In this project, our goal is the functional characterization of subunit 5 of APC from Arabidopsis thaliana, through the production of transgenic plants overexpressing the gene, therefore understand its function for plant development. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE OLIVEIRA, PERLA NOVAIS; DA SILVA, LUIS FELIPE CORREA; ELOY, NUBIA BARBOSA. The role of APC/C in cell cycle dynamics, growth and development in cereal crops. FRONTIERS IN PLANT SCIENCE, v. 13, p. 13-pg., 2022-09-29. (21/03212-5, 21/06611-8, 17/10333-8)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SILVA, Luís Felipe Correa da. Functional characterization of APC5 in Arabidopsis thaliana. 2023. Master's Dissertation - Universidade de São Paulo (USP). Escola Superior de Agricultura Luiz de Queiroz (ESALA/BC) Piracicaba.