Potentially active anti-chagas disease: design and synthesis of molecular hybrid of enzymes superoxide dismutase and CYP51 with nitric oxide releasing group

• Grant number: 21/04778-2
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: August 01, 2021
• End date: July 31, 2023
• Field of knowledge: Health Sciences - Pharmacy
• Principal Investigator: Elizabeth Igne Ferreira
• Grantee: Erick Tavares Marcelino Alves
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated scholarship(s): 22/13442-0 - QSAR-driven discovery of bioactive compounds against CYP51 of Trypanosoma cruzi, BE.EP.IC

Abstract

Considering that only nifurtimox and benznidazole are drugs available for Chagas disease, being less effective in the treatment of chronic phase of this disease, and, in addition, that this is a neglected disease, there is an urgent need for new and better chemotherapeutic agents, especially for chronic phase. Motivated by the urgency of finding new antichagasic agents, the objective of this project is to explore studies related to multi-target compounds, as a molecular hybrid of Fe-superoxide dismutase, Fe-SOD dismutase, and Cyp-51 with a releasing nitric oxide group. We expect that the designed molecule can act against T. cruzi in those targets, thus containing groups as acetophenone, piperazine, and furoxane. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PERNICHELLE, FILIPE GOMES; ALVES, ERICK TAVARES MARCELINO; SERAFIM, RICARDO AUGUSTO MASSARICO; FERREIRA, ELIZABETH IGNE. The Importance of the Piperazine Ring for the Development of Trypanomicide Compounds. CHEMISTRYSELECT, v. 8, n. 33, p. 25-pg., 2023-09-05. (20/13347-2, 21/04778-2)

ALVES, ERICK TAVARES MARCELINO; PERNICHELLE, FILIPE GOMES; NASCIMENTO, LUCAS ADRIANO; FERREIRA, GLAUCIO MONTEIRO; FERREIRA, ELIZABETH IGNE. Covalent Inhibitors for Neglected Diseases: An Exploration of Novel Therapeutic Options. PHARMACEUTICALS, v. 16, n. 7, p. 40-pg., 2023-07-01. (20/13347-2, 21/04778-2)