Incidence of bisphenol A, benzophenones and polycyclic aromatic hidrocarbons in human milk: an exploratory study

• Grant number: 21/02153-5
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: August 01, 2021
• End date: February 28, 2025
• Field of knowledge: Agronomical Sciences - Food Science and Technology - Food Science
• Principal Investigator: Helena Teixeira Godoy
• Grantee: Marcella Vitoria Galindo
• Host Institution: Faculdade de Engenharia de Alimentos (FEA). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated scholarship(s): 22/06633-4 - Development of a multi-residue method for the simultaneous detection of pesticides and mycotoxins in infant formulae, BE.EP.DR

Abstract

Human milk is the main source of nutrients for infants during the first months of life. However, human milk might contain toxic chemical substances, which cause harm to infants due to the vulnerability of the organism, which is still underdeveloped and unable to efficiently metabolize and excrete toxic chemicals. Substances such as Bisphenol A (BPA), Benzophenones (BPs) and Polycyclic Aromatic Hydrocarbons (PAHs) are present in milk as a consequence of the mothers' lifestyle and diet. In this context, the present work aims to develop and validate analytical methods to evaluate the occurrence of these three classes of contaminants (BPA, BPs and HPAs) in human milk samples from São Paulo. For this, It will be developed ecofriendly sample preparation techniques, such as QuEChERS and d-SPE, associated with gas or liquid chromatography and, coupled to mass spectrometry to detect these compounds. The reported results might assist regulatory agencies in the formulation of scientific opinions and databases still scarce in Brazil, in order to guarantee the quality of human milk and the safety of mothers and infants. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GALINDO, MARCELLA VITORIA; HANTAO, LEANDRO WANG; SAMPAIO, NAIARA MARIANA FIORI MONTEIRO; PESSOTO, MONICA APARECIDA; DA SILVA OLIVEIRA, WELLINGTON; GODOY, HELENA TEIXEIRA. Analysis of polycyclic aromatic hydrocarbons in Brazilian human milk: A simple and effective approach. FOOD CONTROL, v. 167, p. 10-pg., 2024-08-12. (21/02153-5)

GALINDO, MARCELLA VITORIA; VARGAS-PEREZ, MARTA; LOPEZ-RUIZ, ROSALIA; OLIVEIRA, WELLINGTON DA SILVA; GODOY, HELENA TEIXEIRA; GARRIDO-FRENICH, ANTONIA; ROMERO-GONZALEZ, ROBERTO. Monitoring of pesticide residues in Brazilian infant formulas using the suspect screening methodology by GC-HRMS. Journal of Food Composition and Analysis, v. 139, p. 5-pg., 2024-12-27. (22/06633-4, 21/02153-5)

GALINDO, MARCELLA VITORIA; LOPEZ-RUIZ, ROSALIA; OLIVEIRA, WELLINGTON DA SILVA; GODOY, HELENA TEIXEIRA; FRENICH, ANTONIA GARRIDO; ROMERO-GONZALEZ, ROBERTO. Comprehensive analysis of contaminants in Brazilian infant formulas: Application of QuEChERS coupled with UHPLC-QqQ-MS/MS and suspect screening-unknown analysis by UHPLC-Q-Orbitrap-MS. Journal of Chromatography A, v. 1726, p. 12-pg., 2024-05-14. (21/02153-5, 22/06633-4)