Computational studies, synthesis and pharmacological evaluation of novel phthalimide derivatives for the treatment of Malaria

• Grant number: 21/03565-5
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: August 01, 2021
• End date: July 31, 2022
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Nailton Monteiro Do Nascimento Júnior
• Grantee: Bruna Cristina Lopes Domingues
• Host Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

Malaria is caused by species of Plasmodium spp. It is estimated that 228 million cases and 405 thousand deaths were reported worldwide in 2018 due to this disease. In addition, the parasites are acquiring resistance to the drugs currently available for treatment. Therefore, it is extremely urgent to develop novel drugs candidates against this disease. In this context, this project aims to carry out the virtual screening of 48 phthalimide derivatives with potential antimalarial activity and then synthesize the 8 most promising ones for further pharmacological evaluation. (AU)