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APC as an entry point to study small molecule regulation of the cell cycle

Grant number: 21/06611-8
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): August 01, 2021
Effective date (End): July 31, 2023
Field of knowledge:Biological Sciences - Biochemistry - Molecular Biology
Cooperation agreement: Max Planck Society for the Advancement of Science
Principal researcher:Nubia Barbosa Eloy
Grantee:Perla Novais de Oliveira
Home Institution: Escola Superior de Agricultura Luiz de Queiroz (ESALQ). Universidade de São Paulo (USP). Piracicaba , SP, Brazil
Associated research grant:17/10333-8 - APC as an entry point to study small molecule regulation of the cell cycle, AP.JP

Abstract

The anaphase-promoting complex/cyclosome (APC/C) is a multi-subunit E3 ubiquitin ligase that plays a major role in the progression of the eukaryotic cell cycle. This unusual protein complex targets key cell-cycle regulators, such as mitotic cyclins and securins, for degradation via the 26S proteasome by ubiquitination, triggering the metaphase-to-anaphase transition and exit from mitosis. The identification of the complete set of genes encoding subunits of the APC in Arabidopsis suggests that the basic processes controlled by proteolysis mediated by ubiquitin in plants are similar to those of other organisms. However, results from several groups indicate that the APC has other specific functions in the regulation of plant development. During the last years, several molecular-biology tools have been extensively used in scientific research for identifying new function of proteins and metabolites. Still, the identification of metabolites, specially which control the cell cycle is not trivial and is characterized by piecemeal progress, especially in plants. In this project we aim to use metabolomics to identify and characterize metabolites that bind to the APC in the model plant Arabidopsis, and to potentially define their roles in plant development. (AU)

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