Intestinal effects of Nicotinamide Riboside and Pterostilbene: an investigation about permeability, mucus production and nutrient absorption

• Grant number: 21/08370-8
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: October 01, 2021
• End date: July 31, 2024
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Licio Augusto Velloso
• Grantee: Raul Gobato da Costa
• Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 13/07607-8 - OCRC - Obesity and Comorbidities Research Center, AP.CEPID

Abstract

Our group has been studying oral supplementation of Nicotinamide Riboside (NR) and Pterostilbene (PT) in the context of aging (2017/01184-9). The results of this thematic study indicate that oral supplementation of NR, PT, and NRPT modulates intestinal physiology aspects. We saw lower intestinal permeability and a higher quantity of goblet cells in intestinal segments of male mice treated with NR, PT, or NRPT. PT had the capacity to lower the body weight gain in animals on a chow diet and ad libtum. The alterations of body weight induced by PT were not dependent on the changes in food ingestion and energy expenditure in mice. On the other hand, we observed higher energy loss in the mice's feces, indicating that PT oral supplementation induced different intestinal effects. (AU)