Advanced search
Start date
Betweenand

Exosomes as mediators of radioresistance in canine glioma

Grant number: 19/27144-9
Support Opportunities:Scholarships abroad - Research
Start date: August 01, 2022
End date: July 31, 2023
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Pathology
Principal Investigator:Ricardo de Francisco Strefezzi
Grantee:Ricardo de Francisco Strefezzi
Host Investigator: David John Argyle
Host Institution: Faculdade de Zootecnia e Engenharia de Alimentos (FZEA). Universidade de São Paulo (USP). Pirassununga , SP, Brazil
Institution abroad: University of Edinburgh, Scotland  

Abstract

Radiotherapy is a key treatment modality for brain tumours, but its efficacy is limited by radioresistance. Cancer stem cells (CSC) have been associated with radioresistance and cancer cell survival is influenced by the exosomal content. The purpose of the present research project is to investigate the role of exosomes in the acquisition of resistance to ionising radiation. To test the hypothesis that brain cancer cell-derived exosomes play a role in the acquisition of radioresistance, we will establish a panel of radioresistant (RR) canine and human glioma cell lines. The exosomes derived from the RR cells will be used to treat non-RR cancer cells and their effect on the CSC population will be quantified. Finally, we will profile the exosome content in order to identify possible new targets to cancer treatment. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
More itemsLess items
Articles published in other media outlets ( ):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)