Evaluation of 11C-PK11195 metabolites in venous blood of people with Down Syndrome
Translational neuroimaging in intellectual disability: evaluation of molecular cha...
Evaluation of molecular changes associated with aging in the Down Syndrome animal ...
Behavioral and histological evaluation of an animal model of Down Syndrome
Nutritional status and diet assessment of children and adolescents with Down Syndrome
Study of the modulator role of Klotho protein in neuroinflammatory signaling in mice
Biomarkers in Down Syndrome
Down syndrome (DS) is a genetic disorder, of great prevalence in the population, characterized by trisomy 21. Its characteristics include intellectual disability, cardiovascular anomalies, immune system alterations and the early development of Alzheimer´s disease (AD). In the context, the use of a noninvasive imaging tool, such as positron emission tomography (PET) can be of great importance in the study of neuroinflammation during aging of people with DS, associated with AD. The main objective of this study is to evaluate glial activation during aging of people with DS by PET imaging with a specific radiopharmaceutical (11C-PK11195). This work is characterized as a "proof of concept" study, in which 50 subjects of different age groups will participate. These will be prepared for the acquisition of images in the PET/RM equipment of the Nuclear Medicine Center of the Faculty of Medicine of the University of São Paulo (FMUSP). The images will be evaluated by validated software for analysis of PET images, PMOD © (PMOD Technologies) and the results will be determined as to statistical significance in appropriate software. After the acquisition of the images and the careful analysis of the obtained data, the preparation of the dissertation will be performed with the description of the literature and the results obtained. (AU)