PET imaging for the evaluation of neuroinflammation in the aging of people with Down Syndrome

• Grant number: 20/11728-9
• Support Opportunities: Scholarships in Brazil - Master
• Effective date (Start): December 01, 2021
• Effective date (End): January 31, 2023
• Field of knowledge: Health Sciences - Medicine - Medical Radiology
• Acordo de Cooperação: Instituto Jô Clemente
• Principal Investigator: Daniele de Paula Faria
• Grantee: Laura Cavalcanti de Oliveira
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 18/15167-1 - Translational neuroimaging in intellectual disability: evaluation of molecular changes associated with aging in Down Syndrome, AP.JP
• Associated scholarship(s): 22/06515-1 - Image-derived input function in PET studies: an exploration of its application in the quantification process, BE.EP.MS

Abstract

Down syndrome (DS) is a genetic disorder, of great prevalence in the population, characterized by trisomy 21. Its characteristics include intellectual disability, cardiovascular anomalies, immune system alterations and the early development of Alzheimer´s disease (AD). In the context, the use of a noninvasive imaging tool, such as positron emission tomography (PET) can be of great importance in the study of neuroinflammation during aging of people with DS, associated with AD. The main objective of this study is to evaluate glial activation during aging of people with DS by PET imaging with a specific radiopharmaceutical (11C-PK11195). This work is characterized as a "proof of concept" study, in which 50 subjects of different age groups will participate. These will be prepared for the acquisition of images in the PET/RM equipment of the Nuclear Medicine Center of the Faculty of Medicine of the University of São Paulo (FMUSP). The images will be evaluated by validated software for analysis of PET images, PMOD © (PMOD Technologies) and the results will be determined as to statistical significance in appropriate software. After the acquisition of the images and the careful analysis of the obtained data, the preparation of the dissertation will be performed with the description of the literature and the results obtained. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE OLIVEIRA, LAURA CAVALCANTI; DE PAULA FARIA, DANIELE. Pharmacological Approaches to the Treatment of Dementia in Down Syndrome: A Systematic Review of Randomized Clinical Studies. Molecules, v. 27, n. 10, p. 11-pg., 2022-05-01. (18/15167-1, 20/11728-9)