Muscle mass and strength as predictors of time to medical discharge and mortality in patients hospitalized with SARS-CoV-2: a prospective observational study

• Grant number: 20/08091-9
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Effective date (Start): December 01, 2021
• Effective date (End): June 30, 2023
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Hamilton Augusto Roschel da Silva
• Grantee: Saulo dos Santos Gil
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The Severe Acute Respiratory Syndrome induced by the new Coronavirus (SARS-CoV-2) has been declared a worldwide pandemic. Identifying common characteristics of the disease is crucial to promote a better prognosis for patients and to reduce the occurrence of medical complications, the time to medical discharge and mortality rates. Muscle mass and strength are recognized predictive measures of medical complications and mortality in different populations, but it is still unclear whether these also applies to patients with SARS-CoV-2. Therefore, this study will investigate whether muscle mass and/or muscle strength are predictors of the time until medical discharge of patients hospitalized with SARS-CoV-2. Muscle mass (via ultrasound) and muscle strength (via handgrip) of patients with SARS-CoV-2 will be assessed upon admission, medical discharge, and 180 days after medical discharge. The time until medical discharge and any medical complications will be recorded. Throughout the hospitalization period, the mortality rate will also be assessed. One hundred and eighty days after medical discharge, the number of hospital readmissions, mortality rate and the use of public health services will be evaluated, to estimate the cost of each patient to the health service. Patients will be stratified according to muscle mass and strength assessed at admission. Data will be analyzed using a mixed model with repeated measures assuming group (percentiles) and time (admission, medical discharge, and 180 days after medical discharge) for each dependent variable. In the event of a significant F-value, Tukey-Kramer post hoc adjustments will be used for multiple purposes. Survival rate will be examined using the Kaplan-Meier curve and analyzed using the Log-rank test (Mantel-Cox). The level of significance will be set apriori at Pd0.05. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GIL, SAULO; JACOB FILHO, WILSON; SHINJO, SAMUEL KATSUYUKI; FERRIOLLI, EDUARDO; BUSSE, ALEXANDRE LEOPOLD; AVELINO-SILVA, THIAGO JUNQUEIRA; LONGOBARDI, IGOR; DE OLIVEIRA JUNIOR, GERSIEL NASCIMENTO; SWINTON, PAUL; GUALANO, BRUNO; et al. Muscle strength and muscle mass as predictors of hospital length of stay in patients with moderate to severe COVID-19: a prospective observational study. JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE, SEP 2021. (17/13552-2, 20/08091-9)

SEKIYA, FELIPE SEITI; DA SILVA, CLARISSE PEREIRA NUNES; OBA-SHINJO, SUELI MIEKO; SANTOS-BEZERRA, DANIELE PEREIRA; RAVAGNANI, FELIPE GUSTAVO; PASQUALUCCI, CARLOS AUGUSTO; GIL, SAULO; GUALANO, BRUNO; BAPTISTA, MAURICIO DA SILVA; CORREA-GIANNELLA, MARIA LUCIA; et al. Identification of two patterns of mitochondrial DNA-copy number variation in postcentral gyrus during aging, influenced by body mass index and type 2 diabetes. Experimental Gerontology, v. 168, p. 8-pg., 2022-08-23. (17/13552-2, 20/02988-7, 20/08091-9, 13/07937-8, 16/15603-0)

GIL, SAULO; KIRWAN, JOHN P.; MURAI, IGOR H.; DANTAS, WAGNER S.; ABUJABRA MEREGE-FILHO, CARLOS ALBERTO; GHOSH, SUJOY; SHINJO, SAMUEL K.; PEREIRA, ROSA M. R.; TEODORO, WALCY R.; FELAU, SHEYLLA M.; et al. A randomized clinical trial on the effects of exercise on muscle remodelling following bariatric surgery. JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE, OCT 2021. (20/08091-9, 16/10993-5)

GIL, SAULO; GUALANO, BRUNO; DE ARAUJO, ADRIANA LADEIRA; DE OLIVEIRA JUNIOR, GERSIEL NASCIMENTO; DAMIANO, RODOLFO FURLAN; PINNA, FABIO; IMAMURA, MARTA; ROCHA, VANDERSON; KALLAS, ESPER; BATISTELLA, LINAMARA RIZZO; et al. Post-acute sequelae of SARS-CoV-2 associates with physical inactivity in a cohort of COVID-19 survivors. SCIENTIFIC REPORTS, v. 13, n. 1, p. 8-pg., 2023-01-05. (17/13552-2, 20/08091-9)

LONGOBARDI, IGOR; GOESSLER, KARLA; DE OLIVEIRA JR, GERSIEL NASCIMENTO; DO PRADO, DANILO MARCELO LEITE; SANTOS, JHONNATAN VASCONCELOS PEREIRA; MELETTI, MATHEUS MOLINA; DE ANDRADE, DANIELI CASTRO OLIVEIRA; GIL, SAULO; BOZA, JOAO ANTONIO SPOTT DE OLIVEIRA; LIMA, FERNANDA RODRIGUES; et al. Effects of a 16-week home-based exercise training programme on health-related quality of life, functional capacity, and persistent symptoms in survivors of severe/critical COVID-19: a randomised controlled trial. BRITISH JOURNAL OF SPORTS MEDICINE, v. N/A, p. 10-pg., 2023-05-09. (20/08091-9, 19/18039-7, 17/13552-2, 21/13580-1, 20/15678-6, 20/07540-4)