On the search of a new catalysts for oxidation reactions of C-H bonds

• Grant number: 21/07167-4
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: March 01, 2022
• End date: February 28, 2027
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Emílio Carlos de Lucca Júnior
• Grantee: Milena Cristina Vieira Fernandes
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 18/04837-6 - Oxidation of aliphatic C-H bonds catalyzed by transition metals, AP.JP

Abstract

The research field of CH bond functionalization has been growing over the last few years, mainly due to the attractiveness of the possibility of chemo- and sitioselectively oxidizing CH bonds with high yields in late-stage synthesis of organic molecules. Many catalysts were developed recently, however there are still several challenges not overcome by this catalyst, such as incompatibility with substrates with functional groups such as olefins and aromatic rings and the oxidation of methyl groups. In view of this scenario, the present work presents a synthesis proposal of a catalyst class to solve some of the mentioned challenges. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SANTANA, VICTOR C. S.; FERNANDES, MILENA C., V; CAPPUCCELLI, ISADORA; RICHIERI, ANA CAROLINA G.; DE LUCCA JR, EMILIO C.. Metal-Catalyzed C-H Bond Oxidation in the Total Synthesis of Natural and Unnatural Products. SYNTHESIS-STUTTGART, v. 54, n. 24, p. 23-pg., 2022-10-06. (18/04837-6, 19/27528-1, 21/07167-4)