Synthesis, characterization, and anticancer activity of the complex [Fe(CN)3 (NO)(CIMTSC)] (CIMTSC = trans-cinnamaldehyde-N(4)-methyl-thiosemicarbazone)

• Grant number: 22/00019-2
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: April 01, 2022
• End date: March 31, 2023
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
• Principal Investigator: José Clayston Melo Pereira
• Grantee: Eduarda Lizier Ribeiro
• Host Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

Cancer is one of the most common causes of death in the world and its incidence is constantly growing, currently in second place in most countries. The treatment of this disease has several possibilities, including chemotherapy, radiotherapy, and surgical removal. In chemotherapy, the drugs used can be organic compounds or coordination complexes. This study proposes the synthesis and evaluation of the anticancer activity of nitrosyl cyanoferrate complex coordinated trans-cinnamaldehyde-N(4)-methyl-thiosemicarbazone against human cells lines ATCC-CRL-9446 (melanoma) and normal human cell line (ATCC -PCS-201-012, skin fibroblast).(AU)