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Relationship between COVID-19 infection and voiding dysfunctions

Grant number: 22/01940-6
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): June 01, 2022
Effective date (End): December 31, 2022
Field of knowledge:Health Sciences - Medicine - Surgery
Principal Investigator:Cássio Luís Zanettini Riccetto
Grantee:Ana Beatriz Fernandes Martins Ferreira
Host Institution: Hospital de Clínicas (HC). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


SARS-CoV-2 infection emerged in China in December 2019, presenting with symptoms similar to viral pneumonia. After its rapid spread through most countries, the disease was declared a pandemic by the World Health Organization in March 2020. More than a year of its discovery, it is now known that despite the virus being a potential cause of acute respiratory syndrome severe, the clinical picture can be varied and accompanied by several extrapulmonary manifestations, including urinary tract involvement. The pathophysiological mechanism associated with the involvement of this system is not yet fully understood, however, it is known that the entry of the virus into urothelial cells triggers an immune response that generates a large amount of pro-inflammatory mediators. These can cause damage to the bladder mucosa, resulting in lower urinary tract symptoms and activation of afferent nerves, influencing bladder function. Justification. In our service, we have observed a significant number of individuals who failed to remove the indwelling urinary catheter after being infected with COVID-19. Patients without previous voiding complaints, who underwent bladder catheterization in the clinical context of the infection, presented urinary retention and other voiding symptoms when the catheter was removed after the infection had resolved. Goals. Define the profile of patients who had voiding dysfunction related to COVID-19 infection and identify risk factors and possible causal factors for voiding dysfunction related to COVID-19methods. A retrospective, multicenter cohort study will be carried out, based on the medical records of patients hospitalized for COVID-19 at HC-UNICAMP and PUC-CAMPINAS hospitals in the period between April 1, 2020, and July 1, 2021, identifying those who presented failure in the attempt to remove an indwelling urinary catheter after extubation and trying to establish risk factors and causal factors.(AU)

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