Sustained hypoxia activate the peripheral chemoreceptors to produce autonomic and respiratory responses to bring back to normal the pressure of oxygen in the arterial blood. The first synapses of the afferents of the peripheral chemoreceptors are in the nucleus tractus solitarius (NTS). These synapses are involved by astrocytes and constitute the synpases tripartite. The interaction of astrocytes and neurons at the level of the synaptic cleft facililate the functional interaction among these cells and it can modulate the synaptic transmission. However, we still dont know in what extension the effects of sustained hypoxia on the neurotransmission at the NTS level involved the astrocytic modulation and this is the main focus of this project.
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