Resolution and post-resolution of inflammation: what role of macrophages in adapted-homeostasis?

• Grant number: 22/07485-9
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• Start date: October 01, 2022
• End date: September 30, 2023
• Field of knowledge: Health Sciences - Dentistry - Periodontology
• Principal Investigator: Luis Carlos Spolidorio
• Grantee: Jhonatan de Souza Carvalho
• Supervisor: Derek W. Gilroy
• Host Institution: Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
• Institution abroad: University College London (UCL), England
• Associated to the scholarship: 20/11672-3 - Eriocitrin: implications on inflammation pro-resolutive markers, BP.DR

Abstract

New knowledge about the ways in which inflammation is resolved signals opportunities for the development of new therapeutic approaches complementary or superior to those traditionally used. Currently, we are investigating the influence of eriocitrin on pro-resolutive events and in macrophage polarization (FAPESP 2020/11672-3). We hypothesized that eriocitrin favors macrophage polarization to a pro-resolutive M2-phenotype, driving the inflammation relief process. However, after resolution, a new phase of local immune regulation has been observed and given the name "adapted-homeostasis". This hitherto unappreciated phase shows a clinically silent immune-response characterized by infiltration of mononuclear phagocytes with a similar phenotype to those for wound repair and immune regulation (M2-macrophage). Thus, we propose in collaboration with Prof. Dr. Derek W. Gilroy (University College London) to investigate the kinetics and phenotype of post-resolution macrophages during adapted homeostasis due to the unknown role of mononuclear phagocytes in post-resolution responses to infection and injury during this phase. These findings will allow us to understand these novel protective pathways and contribute to the development of targets that better treat, predict, or even prevent chronic inflammatory diseases. (AU)