Developing new components and processes in visible light activated biosensors

• Grant number: 22/00243-0
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
• Start date: October 21, 2022
• End date: October 06, 2023
• Field of knowledge: Physical Sciences and Mathematics - Physics - Condensed Matter Physics
• Principal Investigator: Osvaldo Novais de Oliveira Junior
• Grantee: Jose Luiz Bott Neto
• Supervisor: Frank Marken
• Host Institution: Instituto de Física de São Carlos (IFSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
• Institution abroad: University of Bath, England
• Associated to the scholarship: 19/13514-9 - Electrochemical sensors with a matrix containing graphene quantum dots or nanoribbons for the detection of biomarkers, BP.PD

Abstract

Photoelectrochemical (PEC) biosensors operating under visible LED light irradiation are promising for portable devices that enable detection of tumor markers at very low concentrations. This development requires high-performance PEC sensing platforms in which light pulses create locally high ion fluxes that are sensitive to steric hindrance effects from bio-recognition. In this work, we shall investigate and fabricate PEC biosensors with sensitization of the TiO2 nanocrystalline rods grown onto titanium microwire. The activity under visible light irradiation will be enhanced by gold electrodeposition and functionalizing the system with organic molecules such as L-cysteine, 3-mercaptopropionic acid, and p-aminobenzoic acid. Because an optimization step is essential to reach the necessary performance, the materials will be characterized, and their properties correlated with the photoactivity and computer studies. We will seek to understand the processes involved in the sensitization of TiO2 nanocrystalline rods in the presence of these organics as well as their impact on the performance of the biosensor. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BOTT-NETO, JOSE L.; MARTINS, THIAGO S.; OLIVEIRA, OSVALDO N.; MARKEN, FRANK. Controlled electrodeposition of brookite TiO₂ for photoelectroanalysis at printed carbon electrodes. Applied Surface Science, v. 640, p. 7-pg., 2023-12-15. (19/13514-9, 18/22214-6, 22/03758-0, 22/00243-0)