Synthesis, characterization and antiviral activity studies of Pd(II) with aminoadamantanes complexes

• Grant number: 22/08320-3
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: September 01, 2022
• End date: July 29, 2024
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
• Principal Investigator: Pedro Paulo Corbi
• Grantee: Laura Barros Silva
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated scholarship(s): 23/14245-7 - SYNTHESIS, CHARACTERIZATION AND ANTIVIRAL STUDIES OF NOVEL Pd(II) COMPLEXES WITH AMINOADAMANTANES, BE.EP.IC

Abstract

The growing demand for new alternatives in the treatment of infectious diseases makes the search for new drugs with antibacterial, antifungal, and antiviral action extremely important. The modification of existing drugs or their combination with other species active on microorganisms is an interesting strategy to obtain new molecules with the potential for clinical use. Amantadine and memantine are drugs of the aminoadamantane class with recognized medicinal activities. Some of these molecules are used in the treatment of diseases caused by the Influenza A virus and Alzheimer's disease, respectively. Recently, new complexes of Pt(II) and Ag(I) with aminoadamantanes were prepared and reported in the literature by our group. Such compounds showed promising results as antimicrobial agents. In this project, new Pd(II) complexes with the aminoadamantanes amantadine and memantine will be synthesized, characterized, and evaluated for their antiviral activities. The complexes will be prepared from metabolic solutions of the ligands and the palladium metal salt (Li2PdCl4), and characterized by chemical and spectroscopic analyses. The antiviral activity of the compounds will be evaluated by the quantification of viral load by luminescence using the Renilla luciferase assay. Initially, the complexes will be tested in vitro on Chikungunya virus (CHIKV), which is the etiological agent of Chikungunya Fever, and the results obtained will be compared with other agents studied for the same purpose.(AU)