Electrochemical synthesis of sulfones via three-component reaction between alkyl carboxylic acids, sulfur dioxide, and tetrahydroisoquinolines/tetrahydro-beta-carbolines

• Grant number: 22/07836-6
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
• Start date: November 01, 2022
• End date: October 31, 2023
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Ronaldo Aloise Pilli
• Grantee: Aloisio de Andrade Bartolomeu
• Supervisor: Siegfried R. Waldvogel
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Institution abroad: Johannes Gutenberg University Mainz (JGU), Germany
• Associated to the scholarship: 20/07991-6 - Preparation and biological evaluation of phosphoryl and phosphonyl derivatives of goniothalamin and piplartine, BP.PD

Abstract

Molecules containing a sulfonyl (-SO2-) functionality are valuable building blocks in organic synthesis, medicinal chemistry, and pharmaceutical industry. Over the last few years, there has been an increasing interest in the development of methods for the synthesis of the sulfonyl moiety by direct incorporation of SO2. This research project aims the preparation of sulfones using an electrochemical three-component reaction involving alkyl carboxylic acids, sulfur dioxide, and tetrahydroisoquinolines/tetrahydro-beta-carbolines. (AU)