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Photocatalysis applied to difunctionalization of alkenes via CO2 incorporation: multicomponent synthesis of ²-sulfonil and ±- (2-sulfenyl-indolyl) -carboxylic acids

Grant number: 21/01354-7
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): July 01, 2021
Effective date (End): February 29, 2024
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal researcher:Márcio Weber Paixão
Grantee:Kimberly Benedetti Vega
Home Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
Associated research grant:14/50249-8 - Green chemistry: sustainable synthetic methods employing benign solvents, safer reagents, and bio-renewable feedstock, AP.PCPE


The compounds containing different functional groups are of considerable importance in the theoretical understanding of the transformations that lead to their synthesis and in the application of new molecules in synthetic organic chemistry. Interestingly, the chemical properties of each functional group can be changed through steric and electronic modifications, combined with the effects of the adjacent functional groups. Therefore, new chemical properties can be expected for such compounds, which can lead to the development of molecules with a wide application in the pharmaceutical, materials or fine chemistry fields. One of the approaches of chemistry that reaches the synthesis of densely functionalized compounds is the visible light photoredox catalysis, which, unlike classical approaches, offers access to transformations of target molecules efficiently, under milder conditions that are in line with the precepts of green chemistry. In this sense, this project aims to develop two protocols aimed at forming C - S and C - C bonds, addressing the photochemical concepts related to photocatalytic carbosulfonylation/sulfenylation of electron-rich species using CO2 and R-SO2Na/RSH. These protocols will provide the obtaining of several compounds with biological potential, which will be evaluated against the new Coronavirus (SARS-CoV-2). (AU)

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