The polycomb complex PRC2/EZH2 is activated in aggressive cancer and induces gene silencing through histone modifications and chromatin accessibility. However, the mechanism underlying the activation of EZH2 gene expression in thyroid cancer is under investigation. In this context, the molecular investigation of the promoter region of EZH2 could contribute to the identification of transcription factors that control its activation and its relationship with the main genetic alterations detected in thyroid cancer. In this project, we aim to investigate the mechanism of EZH2 promoter gene activation in aggressive thyroid cancer using initially gene reporter assay to delimitate the minimal promoter region. We expect to identify the transcription factors that interact with EZH2 promoter and influence thyroid cancer oncogenesis.
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