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Analysis of EZH2 promoter region in thyroid cancer

Grant number: 22/09813-3
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): September 01, 2022
Effective date (End): August 31, 2023
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Cesar Seigi Fuziwara
Grantee:Marcella Maringolo Cristovão
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:19/17282-5 - Transcriptional and post-transcriptional control in aggressive cancer and metastasis, AP.JP


The polycomb complex PRC2/EZH2 is activated in aggressive cancer and induces gene silencing through histone modifications and chromatin accessibility. However, the mechanism underlying the activation of EZH2 gene expression in thyroid cancer is under investigation. In this context, the molecular investigation of the promoter region of EZH2 could contribute to the identification of transcription factors that control its activation and its relationship with the main genetic alterations detected in thyroid cancer. In this project, we aim to investigate the mechanism of EZH2 promoter gene activation in aggressive thyroid cancer using initially gene reporter assay to delimitate the minimal promoter region. We expect to identify the transcription factors that interact with EZH2 promoter and influence thyroid cancer oncogenesis.

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