Rational design and synthesis of new indolizines of synthetic and medicinal interest

• Grant number: 22/06051-5
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: October 01, 2022
• End date: March 29, 2026
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Giuliano Cesar Clososki
• Grantee: Victor Hugo Catricala Fernandes
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated scholarship(s): 23/16292-2 - DEVELOPMENT OF A NOVEL ALLOSTERIC CD73 INHIBITOR AND PET TRACER., BE.EP.DR

Abstract

Among the N-heterocyclic compounds, indolizines stand out for their great scientific and technological potential, especially in the field of Medicinal Chemistry. This nucleus has as its main structural characteristic, two fused rings, one of the pyridine type and the other of the pyrrole type. Indolizine is an important bioisostere of the indole nucleus, being considered a pharmacological structure due to its great potential, showing anti-inflammatory, antiproliferative, antifungal, larvicidal, antigenic, antituberculosis and antioxidant properties. Additionally, some indolizines have fluorescent properties in the UV-visible region, being applied as biosensors, luminescent probes and carriers of biologically active substances. In this project, a study is proposed, aiming at the planning and functional synthesis of new indolizines with antitumor properties. In this sense, the biological characteristics as much as the biological activity will be considered. In addition, with the objective of optimizing accordingly with the tested activities, late functionalization strategies will be employed implementing changes in a punctual and specific way. In addition to enabling structure-activity studies, when considering the current importance of indolizines, such research proposal may also lead to important contributions to Synthetic Chemistry. (AU)