Cytotoxic profile of hydroxyapatite, curcumin and silver tungstate exposed to white and blue LED light in mouse 3T3 cells

• Grant number: 22/11027-6
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: October 01, 2022
• End date: November 01, 2024
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
• Principal Investigator: Elson Longo da Silva
• Grantee: Paulo Vitor da Costa e Silva
• Host Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
• Associated research grant: 13/07296-2 - CDMF - Center for the Development of Functional Materials, AP.CEPID
• Associated scholarship(s): 24/00743-8 - Synthesis and modification of Ag2WO4 with curcumin by femtosecond for application in wound healing processes, BE.EP.IC

Abstract

Different biological processes occur at the nanometer scale, in this way, nanomedicine aims to develop solutions that act at this level in order to develop therapeutic agents, contrast for exams, among others, that are capable of impacting a certain location directly, without influencing other cells. . Thus, there are several studies that show the benefits of using nanoparticles as an antibacterial and antitumor agent, among others. In addition, phototherapy is constantly being used, as it is a minimally invasive and effective modality that provides a convenient method in the treatment of tumors. Thus, the present project will seek to analyze the cytotoxic profile of some compounds such as hydroxyapatite, curcumin and silver tungstate when exposed to LED light. For this, different methodologies of cytotoxicity analysis will be applied in order to obtain consistent results.