Effects of Ferric Carboximaltosis for the Treatment of Iron Deficiency Anemia in Patients with Crohn's Disease

• Grant number: 21/02997-9
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: November 01, 2022
• End date: October 31, 2023
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal Investigator: Raquel Franco Leal
• Grantee: Dante Orsetti Silva Araujo
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Inflammatory bowel diseases (IBD) are characterized by a chronic and exacerbated inflammatory process of the gastrointestinal tract that occurs due to an idiopathic disorder, with the two main clinical forms being Crohn's disease (CD) and ulcerative colitis (RCU), differing in the location and involvement of the intestinal mucosa layers. The pathophysiology of IBD is not yet fully understood, but it is known that it involves triggering of hyperactivation of effector immune cells in conjunction with inflammatory mediators that trigger the condition. CD exhibits patterns of leaking lesions, which may present in an inflammatory, fistulizing, and fibro-stenosing form. CD triggers several symptoms, with iron deficiency anemia being the most frequent systemic complication, causing several negative impacts on the quality of life of affected patients. The treatment of anemia has obtained satisfactory results through the intravenous application of iron, compared to oral administration. Ferric carboximaltose (Ferinject®) is safe and effective for the treatment of patients with iron deficiency anemia, with CD. Thus, the objective will be to conduct a retrospective study by analyzing the medical records of patients with CD who used this medication during follow-up at the IBD outpatient clinic at Gastrocentro - Unicamp, assessing hematimetric parameters before and after treatment, in addition to collecting epidemiological data and information on the characteristics of CD in these patients.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

NUNES SIQUEIRA, NATALIA SOUZA; PASCOAL, LIVIA BITENCOURT; RODRIGUES, BRUNO LIMA; DE CASTRO, MARINA MOREIRA; CORREA MARTINS, ALAN SIDNEI; SILVA ARAUJO, DANTE ORSETTI; MIANI GOMES, LUIS EDUARDO; CAMARGO, MICHEL GARDERE; SETSUKO AYRIZONO, MARIA DE LOURDES; LEAL, RAQUEL FRANCO. Ferric carboxymaltose for anemia in Crohn's disease patients at a tertiary center: A retrospective observational cohort study. WORLD JOURNAL OF CLINICAL CASES, v. 11, n. 12, p. 14-pg., 2023-04-26. (21/02997-9)