Relationship between immunization level and Covid-19 outcome in patients admitted to a hospital in São Carlos

• Grant number: 22/10728-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: December 01, 2022
• End date: November 30, 2024
• Field of knowledge: Health Sciences - Collective Health - Public Health
• Principal Investigator: Sílvia Carla da Sílva André Uehara
• Grantee: Priscila Poli
• Host Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil

Abstract

To analyze the relationship between the level of immunization of people hospitalized for Covid-19 in a hospital in the city of São Carlos and the outcome. This is a retrospective cohort and will be carried out at Santa Casa de Misericórdia de São Carlos. The population of this study will be composed of people aged 5 years and older who were admitted to wards and/or ICUs with the diagnosis ICD-10 Z20 (Confirmed Covid-19), from February 26, 2021 to February 26, 2023 Data will be collected through medical records and the study variables will be: age, sex, presence of comorbidities, use of invasive mechanical ventilation, length of stay, signs and symptoms and vaccination status. and type of immunization) with the outcome (discharge/death) will be analyzed using generalized linear regression models with Poisson distribution and robust variance, in order to estimate the crude relative risk and adjusted for possible confounding variables (age, sex and presence of comorbidities). In addition, the analyzes will be stratified by type of hospitalization (ward or ICU). The study will be sent to the Research Ethics Committee of the Federal University of São Carlos for consideration.