Characterization of the final height in children with type 1 diabetes diagnosed during the first decade of life

• Grant number: 22/08961-9
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: December 01, 2022
• End date: November 30, 2023
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Raphael Del Roio Liberatore Junior
• Grantee: Camila de Alcantara do Nascimento
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Introduction:Type 1 Diabetes Mellitus is a chronic disease characterized by hyperglycemia due to the absolute deficiency of insulin as a result of the destruction of beta pancreatic cells (GROSS et al, 2002). Little is known about the effect of diabetes in a child's ability to grow, scientific literature is still contradictory both at a national and international scope. On one hand, many studies have shown that patients with type 1 diabetes at prepubertal and pubertal age have a growth restriction which is influenced by glycemic control and progression of the disease (SANTI et al, 2019). Some authors go further to affirm that low stature due to type 1 diabetes is related to the severity of macrovascular complications, being an important factor to predict the patients evolving to microalbuminuria (MITCHELL, 2017). On the other hand, some authors say that the final height in patients diagnosed with type 1 diabetes during childhood seems to be minimally inferior compared to the healthy population (MITCHELL, 2017). Growth velocity during infancy is directly correlated to the child's health. In this sense, a deficit in growth in these patients is an indication that more studies need to be conducted in order to optimize diabetes treatment and reduce long term complications.Objectives: This project aims to characterize growth velocity and final stature in patients diagnosed with type 1 diabetes during the first decade of life in comparison to healthy patients Methods: It will be done a retrospective analysis of hospital records of pediatric patients with type 1 diabetes who had follow ups at the ambulatory of Internal Medicine and Endocrinology Pediatrics at the Clinical Hospital of the School of Medicine of Ribeirão Preto, University of São Paulo (FMRP-USP). Patients will be sorted according to sex, age at diagnosis, median of glicosilated hemoglobin in three periods (pre pubertal, pubertal and post-pubertal).Finally, it will be calculated, in these three pre established periods, the number of standard deviations of growth (Z-score) of the average population, compared to the Z-score of height of the child's family compared to the average population.