Inflammasomes activation in the inflammatory response of deep endometriotic lesions from patients with endometriosis

• Grant number: 22/10279-1
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: December 01, 2022
• End date: May 31, 2026
• Field of knowledge: Health Sciences - Medicine - Maternal and Child Health
• Principal Investigator: Sérgio Podgaec
• Grantee: Helena Malvezzi
• Host Institution: Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE). Sociedade Beneficente Israelita Brasileira Albert Einstein (SBIBAE). São Paulo , SP, Brazil
• Associated scholarship(s): 23/02248-1 - Structural mechanism for inflammasome activation and pyroptosis in endometriosis stromal cells, BE.EP.PD

Abstract

Inflammasomes are macromolecular structures present in the cytoplasm of active immune cells that lead to the activation of caspases and, therefore, the elaboration of an inflammatory response. Activation of capase-1 results in the release of interleukins (IL-) 1B and 18 and induction of cell death by pyroptosis through maturation of cytosolic proteins of the gasdermin family (GSDM). Deregulation in the activation of inflammation is described in the pathogenesis of several inflammatory diseases, including endometriosis. In endometriosis, chronic inflammation is the main molecular and cellular process, responsible for the main symptoms of cyclic and acyclic pain, tissue remodeling, lesions formation, fibrosis and infertility. Inflammation is related to the constant release of cytokines, chemokines, metalloproteinases and growth factors, which contributes to the local inflammation observed both in endometriosis lesions and in the endometrium of these patients. Endometriosis is a benign gynecological disease, affects around 10% of the female population and, being a chronic inflammatory disease, inflammation plays a fundamental role in the maintenance, control of survival and proliferation, cell fate and maintenance of cellular responses. Given the great impact of the activation of inflammasomes on the inflammatory response, it is natural that changes in their activity are related to various inflammatory diseases. Therefore, recognizing and understanding the regulation of inflammasomes holds promise in basic as well as translational research, especially in endometriosis.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MALVEZZI, HELENA; CESTARI, BRUNA AZEVEDO; MENDES, HELEN; HERNANDES, CAMILA; PODGAEC, SERGIO. Peritoneal fluid microbiota profile of patients with deep endometriosis. Microbial Pathogenesis, v. 199, p. 8-pg., 2024-12-23. (22/10279-1)