EVALUATION OF ENCEPHALIC HEMODYNAMICS BY DOPPLER ULTRASONOGRAPHY AND ITS CORRELATIONS WITH INTRACRANIAL PRESSURE VARIATIONS IN AN ANIMAL MODEL OF CEREBRAL SECONDARY INJURY

• Grant number: 22/10956-3
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: February 01, 2023
• End date: January 31, 2024
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal Investigator: Wellingson Silva Paiva
• Grantee: Yasmin Sa Cerqueira
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Introduction: Incracranial hypertension (ICH) is a multifactorial clinical condition that comes with burden on economy - because it requires urgent identification and treatment - and on neurofunctional capacity of the patient, who often suffers irreparable damage to his health. Secondary bleeding, in this case, is common and worsens the brain damage. Transcranial Doppler (TCD) emerges, then, as a non-invasive and more affordable alternative to invasive monitoring of intracranial pressure (ICP). The indication for its use, however, is still conflicting in the literature. The same occurs for hypertonic saline solution (HSS 3%) in the treatment of ICH. Objectives: the primary aim of this study is to perform a comparison of brain hemodynamic assessment in animal models of initial ICH and of secondary injury. Secondary objectives include: to investigate cerebral blood flow by DTC technique and correlate it with ICP variations and to study the effect of intravenous infusion of 3% HSS in both groups. Methods: the values of the ICP and DTC parameters as well as the pulsatility index of two groups of animals (pigs) will be analyzed and compared through means, standard deviations and individual and mean profile graphs. Both were submitted to ICH secondary to hematoma induction by controlled intracranial balloon inflation: in one of the groups, a single 7mL balloon of physiological saline solution was inflated, and in the other, a 4mL and a 3mL balloon of the same solution. Then a 3% HSS venous infusion was administered, and afterwards the balloons were deflated.