Respiratory changes associated to sleep observed in Parkinson's Disease

• Grant number: 22/07705-9
• Support Opportunities: Scholarships abroad - Research
• Start date: July 05, 2023
• End date: July 04, 2024
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Ana Carolina Takakura Moreira
• Grantee: Ana Carolina Takakura Moreira
• Host Investigator: Jan-Marino Ramirez
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Institution abroad: Seattle Children'S Research Institute, United States

Abstract

Parkinson's disease (PD) is a neurodegenerative disease characterized by the death of dopaminergic neurons in the compact portion of the Substantia Nigra (SNc) which promotes the classic motor symptoms that are related to movement: rest tremor, rigidity, bradykinesia and postural instability. Although these symptoms are responsible for the diagnosis of the disease and are the therapeutic target for it, non-classic symptoms can greatly affect the quality of life of patients with PD. Among these symptoms, changes in breathing, sleep and swallowing are present. Previous studies from our laboratory examined that in a neurotoxin experimental model of PD, there are changes in regions that control breathing and that are associated with functional respiratory changes. However, there are still many questions regarding the respiratory changes associated with changes in sleep and swallowing. Thus, the aims of this project are to investigate whether there are changes in sleep and swallowing associated with breathing in an experimental model of PD. (AU)