Evaluation of the renal afferent activation and sympathetic activity in renovascular hypertension mediated by peripheral and central manipulations

• Grant number: 22/06701-0
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: April 01, 2023
• End date: June 06, 2023
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Ruy Ribeiro de Campos Junior
• Grantee: Maycon Igor de Oliveira Milanez
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated research grant: 19/25295-0 - Communication between the central nervous system and kidneys: cardiovascular, renal and autonomic influences in physiological and physiopathological conditions, AP.TEM

Abstract

Sympathoexcitation contributes to the cardiorenal dysfunctions found in 2 kidneys, 1 clip (2K1C) hypertension, raising the need to investigate central changes in the model. Studies have reported changes in several pathways and neurotransmitters responsible for maintaining sympathetic activity in 2K1C animals. However, the impact of these central phenomena on effector functionality is still unclear. The present project seeks to describe possible sympathetic signatures mediated by cardiovascular nuclei and their role in the genesis/maintenance of 2K1C hypertension. Furthermore, studies suggest that renal afferents contribute to sympathoexcitation in the 2K1C animal, thus, in addition to central changes, sensory activity is also contributing to cardiorenal changes in the model. However, the mechanisms involved in sensory changes in the kidneys during the course of renovascular hypertension are not yet fully known, as well as whether this phenomenon precedes the increase in blood pressure levels. The present study aims to investigate the onset of intrarenal sensory dysfunctions and apply approaches to selectively normalize renal afferents in 2K1C hypertension. Thus, the project aims to bring to light possible targets in the treatment of hypertension that encompass two distinct central loops, that is, efferent and afferent renal signaling, and to clarify aspects not yet reported about the pathophysiology of renovascular hypertension.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FABER, JEAN; MILANEZ, MAYCON I. O.; SIMOES, CRISTIANO S.; CAMPOS, RUY R.. Frequency-coded patterns of sympathetic vasomotor activity are differentially evoked by the paraventricular nucleus of the hypothalamus in the Goldblatt hypertension model. FRONTIERS IN CELLULAR NEUROSCIENCE, v. 17, p. 12-pg., 2023-08-22. (22/06701-0, 19/25295-0)