Association between severity of peripheral arterial disease and conditions related to muscle mass and function in patients with atherosclerosis

• Grant number: 23/00225-4
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: May 01, 2023
• End date: February 28, 2025
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Paula Schmidt Azevedo Gaiolla
• Grantee: David do Nascimento Pereira
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
• Associated scholarship(s): 23/11712-3 - Ultrasound imaging analysis and clinical application for the assessment of sarcopenia in patients with atherosclerosis, BE.EP.IC

Abstract

Introduction: Peripheral artery disease (PAD) is a multifactorial syndrome that frequentlyimpacts patients functional ability and muscle strength. It is also known that sarcopenia andPAD are often associated. Although the reduction in skeletal muscle mass is commonly found in patients suffering from chronic peripheral artery obstruction, Sarcopenia is still anunderdiagnosed condition in PAD patients. Problem Statement/Objective: We hypothesizethat Peripheral Artery Disease (PAD) severity is associated with Quadriceps femoris musclestrength and thickness, blood and serum biomarkers might explain sarcopenia and changes in muscle mass and function are related to post surgical complications. Therefore, we aim to investigate if the lower limb muscle strength,muscle quantity/quality, condition and physical performance differs according to the diseaseseverity. Method: We intend to carry out a prospective cohort study withhospitalized PAD patients undergoing revascularization surgical treatment at BotucatuMedical School University Hospital (HCFMB). PAD patients will be submitted toQuadriceps muscle strength assessment with a handheld dynamometer, Bioimpedance indexfor body composition analysis and ultrasound measurement for muscle echogenicity. Inaddition, we plan to use computed tomography (CT) data to measure transversal psoasmuscle thickness, assess functional performance with the mobility TUG test, as well as identify sarcopenia biomarkers by blood and serum biochemical laboratory tests.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FERRO, FLAVIO CRUZ; CAMPOS, MARCOS ADRIANO GARCIA; PICOLLI, THAIS CAROLINE SILVA; MAYORAL, VANIA DE SA; SOARES, VICTORIA MORALEZ; FERREIRA, JESSICA CAROLINE; PERES, LUCAS DIAS BORGES; TIBEAU, THEODOR TERRA MAYER; BERNARDI, VICTOR EL CHIHIMI; PEREIRA, DAVID NASCIMENTO; et al. Performance of the Nottingham hip fracture score (NHFS) as a predictor of 30-day mortality after proximal femur fracture in an older people Brazilian cohort. SCIENTIFIC REPORTS, v. 15, n. 1, p. 12-pg., 2025-02-15. (22/15147-6, 23/00225-4)