Advanced search
Start date
Betweenand

Exploring the role of NRF2-pathway in ferroptosis in cancer cells

Grant number: 23/04397-4
Support Opportunities:Scholarships abroad - Research Internship - Doctorate
Start date: January 01, 2024
End date: August 31, 2024
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Clarissa Ribeiro Reily Rocha
Grantee:Izadora de Souza
Supervisor: José Pedro Friedmann Angeli
Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Institution abroad: Julius-Maximilians-Universität Würzburg (JMU), Germany  
Associated to the scholarship:21/11597-4 - Analysis of the role of NRF2 in ferroptosis modulation in chemotherapy-resistant tumor cell lines, BP.DR

Abstract

Cancer is a leading cause of death worldwide. Although great advances have been made in cancer treatment, chemotherapy resistance remains a great clinical challenge and, as a consequence, it is one of the main causes of failure in most patients with metastatic cancer. NRF2 is an important gene involved in drug resistance and has been identified as amplified in the most aggressive types of cancer. NRF2 regulates genes related to the antioxidant response and is involved in a novel regulated cell death called ferroptosis. Ferroptosis has been intensively studied as an alternative to antitumor therapy since ferroptosis-inducing agents can sensitize several tumors. However, the relationship between NRF2 and ferroptosis remains poorly understood. In fact, depending on the expression of NRF2 targets, this gene can inhibit or induce ferroptosis. Thus, during this BEPE project it is going to be analyzed how NRF2 and its target genes modulate ferroptosis in two different types of cancer cells. To this end, we are going to use a custom CRISPR knockout library targeting the NRF2-pathway to identify the targets of NRF2 that modulate ferroptosis. We strongly believe that this project will contribute to improve our knowledge of the mechanism of ferroptosis induction in glioblastoma and lung cancer, which will help to design more adequate and efficient chemotherapy strategies to treat cancer patients using ferroptosis. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
More itemsLess items
Articles published in other media outlets ( ):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)