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Noninvasive electrocardiographic imaging during atrial fibrillation: an experimental contribution

Grant number: 23/06306-6
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): June 01, 2023
Effective date (End): May 31, 2025
Field of knowledge:Engineering - Biomedical Engineering - Bioengineering
Principal Investigator:João Loures Salinet Júnior
Grantee:Angélica Drielly Santos de Quadros
Host Institution: Centro de Engenharia, Modelagem e Ciências Sociais Aplicadas (CECS). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil
Associated research grant:18/25606-2 - Accurate mapping of cardiac fibrillation activity: an experimental contribution, AP.JP

Abstract

Atrial fibrillation (AF) is the most frequent sustained cardiac arrhythmia in clinical practice, affecting between 1 and 2% of the world population. This disorder has high morbidity and mortality, and has become a chronic non-infectious cardiovascular epidemic, making it an important public health problem, and consumption of health resources. Recently, basic and clinical research has made great advances in the improvement of the diagnosis and treatment of AF, and its mechanism has been gradually elucidated, but not fully clarified. During AF, the interpretation of signals and maps, obtained from commercial electrical mapping systems, is complex and uncertain, hindering the correct characterization and location of arrhythmogenic sources, reducing the efficacy of ablation treatment. The correct identification of the type of mechanism and its location is the current challenge of electrophysiologists. Due to the complexity of this arrhythmia and great sensitivity to errors by current commercial systems, it is important that validations of proposed methods are first validated under controlled experiments by mimetizing clinical situations. The objective of this project is to customize the noninvasive electrocardiographic imaging (iECG) method for the generation of electrophysiological maps of the epicardium in an experimental model in situ of AF induced with electrical stimulation. This will allow the identification of intrinsic patterns of each mechanism in a noninvasive manner, and projected in the epicardium of the heart. The experiments will be conducted in isolated hearts of reperfused rabbits using Langendorff preparation. The induction of AF will be by a protocol of restitution by standard pulse train (S1-S1) in the left atrium. The acquisition of biopotentials in the epicardium will be performed by contact unipolar electrodes. The acquisition of non-invasive electrical activity will be performed through electrodes distributed equally between the faces of a hexagonal acrylic and translucent tank, with heated Tyrode solution (37oC) inside. Thus, the heart will be submerged in the tank with the nutrient solution inside, in order to maintain its physiological activity and drive its electrical impulses to the electrodes of the tank face. From the signs of non-contact will be estimated those of the epicardium by the iECG method through discretization of the 3D surfaces of the epicardium and torso in triangular elements and the use of the Tikhonov regularization method. Signal analysis and 3D maps will be performed using Matlab Version 9.7 (R2019) (Mathworks, Inc.) or Python. Metrics and maps in the time and frequency domain will be calculated from the electrical signals of the epicardium and non-invasive. This will allow the non-invasive classification of AF patterns and the characterization of sand-time patterns. Through a pipeline of pre-processing and post-processing techniques to be applied to the signals obtained by non-invasive electrical mapping, it is intended to generate non-invasive maps during AF more realistic with the pathophysiology of AF. This research project is an interdisciplinary study which face areas of engineering and health, such understanding important aspects in the area of electrophysiological biological signal processing, hardware and animal experimentation, ranging from the validation of techniques to a possible implementation in medical equipment.

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