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Infection of CD4 T lymphocytes by RSV: defective viral genome (DVG) formation and its pro-survival effects on the infected cells

Grant number: 23/07268-0
Support Opportunities:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): September 28, 2023
Effective date (End): September 27, 2024
Field of knowledge:Biological Sciences - Microbiology - Applied Microbiology
Principal Investigator:Eurico de Arruda Neto
Grantee:Rosa Maria Mendes Viana
Supervisor: Carolina Beatriz Lopez Zalaquett
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Research place: University of Washington, United States  
Associated to the scholarship:20/10954-5 - Infection of CD4 T lymphocytes by human respiratory syncytial virus: study of permissiveness, expression of viral genes and cellular repercussions, BP.DR

Abstract

Respiratory syncytial virus (RSV) is the most important viral cause of severe respiratory infections in children worldwide. RSV infects the respiratory epithelium and is also frequently detected in CD4+ T cells from secondary lymphoid tissues of asymptomatic patients. Host factors such as progressive loss of immune functions, and impaired production of cytokines favor the maintenance of persistent infections. During natural RSV infection, copy-back defective viral genomes (DVGs) are produced that trigger an antiviral response, but contradictorily, cbVGs can promote persistent infection. The presence of RSV in secondary lymphoid tissues of patients without acute symptoms of respiratory infection suggests a long-term or persistent infection. Thus, the present study aims to study the association between DVGs and persistent infection in primary culture of CD4+ T lymphocytes. (AU)

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