Study of the interrelationship between angiosomes and their dysfunction in kidney and liver organs in acute sepsis and in sepsis survivors

• Grant number: 23/07392-3
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: July 01, 2023
• End date: June 30, 2024
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Ivan Hong Jun Koh
• Grantee: Gabriel Antônio de Oliveira
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated research grant: 17/21052-0 - Sepsis: mechanisms, therapeutic targets and epidemiology, AP.TEM

Abstract

The results achieved from this thematic project showed us that microcirculatory and adjacent tissue damage in organs does not fully recover in post-sepsis survivors, and the remaining severity was organ-specific. In sepsis survivors, there is a state of microcirculatory dysfunction in the organs that makes intercommunication between the multiple microcirculatory networks distributed throughout the body difficult. These results encouraged us to study the dynamics of the intercommunication of the microcirculatory networks in the kidney and liver organs by means of technology with injection of light resin (Mercox II Resin), a method that may allow evidence of these intercommunications. This methodology differs from studies with SDF videomicroscopy and/or tissue perfusion with Laser Doppler, as these evaluate only focally (five captures/organ with an area of 1mm/capture), not showing the dynamics of microcirculatory reorganization in the entire organ. A better understanding of this phenomenon of microcirculatory adaptation in sepsis and survivors can provide us with the direction of possible therapeutic interventions aimed at recovering from microcirculatory dysfunction, which constitutes one of the main current limitations in critical illnesses in general, including sepsis.